NEW YORK — The Cleveland Indians set the bar for Yankee Stadium's new record book today, scoring 14 runs in the second inning of a 22-4 victory.

Asdrubal Cabrera hit a grand slam and an RBI single in the second as the Indians chased struggling starter Chien-Ming Wang and set several marks that could stand for a while at New York's swanky new home.

Mark DeRosa and Shin Soo-Choo each hit three-run homers, Travis Hafner, Grady Sizemore and Victor Martinez had solo shots and manager Eric Wedge earned his 500th victory. Jhonny Peralta had three hits and two RBIs after missing Friday's 6-5 loss with a strained left elbow.

Mark Teixeira and Melky Cabrera each hit a two-run homer for the Yankees, who have been embarrassed in two of their first three regular-season games at their new field. New York lost 10-2 in its home opener Thursday when Cleveland scored nine runs in the seventh inning.

It was the most runs for the Indians since they beat New York 22-0 on Aug. 31, 2004, at the old Yankee Stadium. The 22 runs also tied the Yankees' record for most allowed in a home game.

The 14 runs and 13 hits by the Indians in the second were the most allowed by the Yankees in an inning.

Choo delivered the first big blow in the second, hitting a three-run homer off Wang to give Cleveland a 3-2 lead. Asdrubal Cabrera singled in a run, DeRosa had a two-run double and Martinez had an RBI single before Wang was replaced by Anthony Claggett, who was making his major league debut after being recalled from Triple-A Scranton/Wilkes-Barre before the game.

Wang (0-3) was charged with eight runs and eight hits in 1 1-3 innings, giving him a 34.50 ERA in three starts this year. He went 5-0 with a 3.23 ERA in six April starts last season.

Peralta doubled in two more runs after Wang left and Asdrubal Cabrera hit a drive to right on a 3-1 pitch for his first homer of the year. Sizemore followed Cabrera's shot with his fourth homer to make it 14-2 as the crowd booed loudly.

The fans started chanting "We want Swisher!" for the second time in the series as Claggett struck out DeRosa for the final out. Yankees outfielder Nick Swisher pitched a scoreless inning during a blowout loss at Tampa Bay on Monday.

Wang and Claggett combined to throw 69 pitches during the half-inning, which lasted 37 minutes.

The "We want Swisher!" chant returned when Hafner hit his fourth homer of the season in the eighth.

Fausto Carmona (1-2) was the beneficiary of the Indians' big day at the plate, working six innings in his first victory of the season. He allowed four runs and six hits.

Carmona surrendered Teixeira's third homer in the first as the crowd of 45,167 found their seats on a picturesque day in New York. Even with the beautiful, 75-degree weather, the 1,800 Legends Suite seats in the first nine rows ringing the plate, which cost between $500 and $2,625 each, had long strings of empty chairs.

DeRosa went 4-for-7 and tied a career high with six RBIs. Cabrera tied a career mark with four hits and five RBIs.